Invitro Anti-arthritic and Anti-inflammatory activities of Rhynchosia rufescens (Willd.)DC. Seed extract on Inhibition of Protein Denaturation

The Rheumatic arthritis is an auto immune inflammatory disorder which cause destruction of cartilage and bone damage with risk of infections. Inflammation is the response of living tissues to injury and is a complex pathophysiological process associated with extravasation of fluid and proteins and accumulation of leukocytes at the site of injury. In the present study, the invitro anti-arthritic and anti-inflammatory activity of the ethanolic seed extract of Rhynchosia rufescens was evaluated with the inhibition of protein denaturation. Diclofenac sodium was used as control drug. The methanolic seed extract shows high percentage of inhibition of protein denaturation in the concentration of 100μl/ml and significant result of anti-inflammatory activity at 250μl/ml concentration. The results suggested that the Rhynchosia rufescens would be a valuable herbal plant for scientific investigations.